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North Cumbria University Hospitals NHS Trust - 70 years of the NHS

Home > Our services > Afshar Sorena

Afshar Sorena


General and Colorectal Surgery

Based at

Cumberland Infirmary, Carlisle

Year qualified


Professional qualifications

PhD, MBChB, FRCSEd, PG Cert Clin Ed

Treatment and procedures

  • Laparoscopic Colorectal Surgery for cancer and benign conditions
  • Diverticular disease
  • Inflammatory bowel disease
  • Haemorrhoid treatments including THD/HALO and haemorrhoidectomy
  • Anal fistula treatments
  • Hernia surgery – laparoscopic and open repair, including procedures under local anaesthesia
  • JAG certified endoscopist – upper GI endoscopy, colonoscopy, flexible sigmoidoscopy and endoscopic removal of polyps

Clinical Interests / specialist areas

Colorectal Cancer

Inflammatory Bowel Disease

Laparoscopic surgery

Medical Education

Professional membership

Association of Coloproctology of Great Britain and Ireland

Fellowship of the Royal College of Surgeons Edinburgh

European Society of Coloproctology


Obesity, weight loss surgery and biomarkers of colorectal cancer risk - PhD research project completed Sep 2016

- To assess if obesity and surgically-induced weight loss influence biomarkers of colorectal cancer risk

- Findings consistent with the hypothesis that surgically-induced weight loss in obese adults may lower CRC risk.

Can mitochondrial DNA mutations predict the effectiveness of chemoradiotherapy in rectal cancer?

- To determine whether mutations in the mitochondrial DNA may help to predict which patients will have a complete response to chemoradiotherapy.

- Running in collaboration with Newcastle University & Northumbria NHS Foundation Trust

Local Colorectal co-PI for the Add-Aspirin trial



Distinction Phase III MBChB Aberdeen University

Carlisle Surgical Prize 2017


BREININGER, S. P., MALCOMSON, F. C., AFSHAR, S., TURNBULL, D. M., GREAVES, L. & MATHERS, J. C. 2019. Effects of obesity and weight loss on mitochondrial structure and function and implications for colorectal cancer risk. Proc Nutr Soc, 1-12.

SU, T., GRADY, J. P., AFSHAR, S., MCDONALD, S. A., TAYLOR, R. W., TURNBULL, D. M. & GREAVES, L. C. 2018. Inherited pathogenic mitochondrial DNA mutations and gastrointestinal stem cell populations. J Pathol.

CIROCCHI, R., AFSHAR, S., SHABAN, F., NASCIMBENI, R., VETTORETTO, N., DI SAVERIO, S., RANDOLPH, J., ZAGO, M., CHIARUGI, M. & BINDA, G. A. 2018. Perforated sigmoid diverticulitis: Hartmann's procedure or resection with primary anastomosis-a systematic review and meta-analysis of randomised control trials. Tech Coloproctol.

AFSHAR, S., MALCOMSON, F., KELLY, S. B., SEYMOUR, K., WOODCOCK, S. & MATHERS, J. C. 2017. Biomarkers of Colorectal Cancer Risk Decrease 6 months After Roux-en-Y Gastric Bypass Surgery. Obes Surg.

CIROCCHI, R., AFSHAR, S., DI SAVERIO, S., POPIVANOV, G., DE SOL, A., GUBBIOTTI, F., TUGNOLI, G., SARTELLI, M., CATENA, F., CAVALIERE, D., TABOLA, R., FINGERHUT, A. & BINDA, G. A. 2017. A historical review of surgery for peritonitis secondary to acute colonic diverticulitis: from Lockhart-Mummery to evidence-based medicine. World J Emerg Surg.

AFSHAR, S., SEYMOUR, K., KELLY, S. B., WOODCOCK, S., VAN HEES, V. T. & MATHERS, J. C. 2016. Changes in physical activity after bariatric surgery: Using objective and self-reported measures. Surgery for Obesity and Related Diseases.

AFSHAR, S. & KURER, M. A. 2016. Laparoscopic peritoneal lavage for perforated diverticulitis: are we any further forward? Colorectal Dis, 18, 937-938.

AFSHAR, S., KELLY, S. B., SEYMOUR, K., WOODCOCK, S., WERNER, A. D. & MATHERS, J. C. 2016. The Effects of Bariatric Procedures on Bowel Habit. Obes Surg.

ASHOR, A. W., SIERVO, M., LARA, J., OGGIONI, C., AFSHAR, S. & MATHERS, J. C. 2015. Effect of vitamin C and vitamin E supplementation on endothelial function: a systematic review and meta-analysis of randomised controlled trials. Br J Nutr, 113, 1182-94.

OSMAN, K. A., RYAN, D., AFSHAR, S., MOHAMED, Z. K., GARG, D. & GILL, T. 2015. Transanal Endoscopic Microsurgery (TEM) for Rectal Cancer: University Hospital of North Tees Experience. Indian J Surg, 77, 930-5.

AFSHAR, S., KELLY, S. B., SEYMOUR, K., LARA, J., WOODCOCK, S. & MATHERS, J. C. 2014. The effects of bariatric surgery on colorectal cancer risk: systematic review and meta-analysis. Obes Surg, 24, 1793-9.

AFSHAR, S. & KURER, M. A. 2012. Laparoscopic peritoneal lavage for perforated sigmoid diverticulitis. Colorectal Dis, 14, 135-42